6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl]
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6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl]
Ichi chigadzirwa ihwendefa yero yero-yakavharwa piritsi, chena kana rinenge chena mushure mekubvisa coating.
Zviratidzo
Ichi chigadzirwa chakakodzera kurapwa kwechirwere cheshuga 2.
Monotherapy
Ichi chigadzirwa chinoshandiswa pamwe chete nekutonga kwekudya uye kurovedza muviri kuvandudza kudzora shuga yeropa kune varwere vane chirwere cheshuga 2.
Inoshandiswa pamwe chete ne metformin hydrochloride
Kana metformin hydrochloride yega isingakwanise kudzora shuga yeropa, chigadzirwa ichi chinogona kushandiswa pamwe chete nemetformin hydrochloride kuvandudza kudzora shuga yeropa kune varwere vane chirwere cheshuga cherudzi rwechipiri pahwaro hwekudya uye kurovedza muviri.
Inoshandiswa pamwe chete ne metformin hydrochloride uye sulfonylureas.
Kana kushandiswa kwakasanganiswa kwe metformin hydrochloride uye sulfonylureas kusingakwanise kudzora shuga yeropa, chigadzirwa ichi chinogona kushandiswa pamwe chete nemetformin hydrochloride uye sulfonylureas kuvandudza kudzora shuga yeropa yevarwere vane Type 2 chirwere cheshuga pahwaro hwekudya uye kurovedza muviri.
Kurambidzwa kwemishonga
Ichi chigadzirwa hachikurudzirwe kune varwere vane Type 1 chirwere cheshuga kana kurapwa kwechirwere cheshuga ketoacidosis.
Tsanangudzo
(1) 10 MG;(2) 25 mg.
Dosage
Inokurudzirwa dose.
Nhamba yakakurudzirwa yechigadzirwa ichi ndeye 10 mg mangwanani, kamwe chete pazuva, padumbu risina chinhu kana mushure mekudya.Mune varwere vanoshivirira chigadzirwa ichi, muyero unogona kuwedzerwa kusvika 25 mg (ona [Clinical Trials]).
Mune varwere vane hypovolemia, zvinokurudzirwa kugadzirisa hypovolemia isati yatanga kushandisa chigadzirwa ichi (ona [Mazano]).
Varwere vane renal impairment.
Zvinokurudzirwa kuti uongorore renal basa usati watanga kushandisa chigadzirwa ichi, uye zvino chinofanira kuongororwa nguva dzose.
Varwere vane eGFR yakaderera pane 45 mL/min/1.73 m2 havafanire kushandisa chigadzirwa ichi.
Varwere vane eGFR yakakwirira kudarika kana yakaenzana ne 45 mL / min / 1.73 m2 haifaniri kugadzirisa dose.
Kana eGFR ikaramba yakaderera pane 45 mL/min/1.73 m2, chigadzirwa ichi chinofanira kuregedzwa (ona [Kungwarira]).
Varwere vane kukuvara kwechiropa.
Varwere vane kukuvara kwechiropa havadi kugadzirisa dose.Enpagliflozin kuratidzwa kwakawedzera muvarwere vane kukuvara kwakanyanya kwechiropa.Chiitiko chekurapa kwevarwere vane kukuvara kwakanyanya kwechiropa kunogumira, saka, hazvikurudzirwe kune chikamu ichi chevanhu.
Standard:bhizinesi standard
kuchena:≥99.0%
Kunze:chena kusvika kuchena-upfu
Pakeji:25kg / chigubhu
JIN DUN Medical aneISO qualification uye inosangana neGMP yekugadzira zviyero, vakashandirwa mudzimba nevekunze nyanzvi dzekugadzira zvinodhaka vane ruzivo rwakapfuma kutungamira R&D yekambani.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Equipments
Yedu Lab ine midziyo yakasiyana-siyana yekuedza uye yekuedza, yakadai se: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Chikwata
Jindun Medical ine boka revashandi veR&D nyanzvi, uye inoshandisa nyanzvi zhinji dzemumba nedzekunze dzekugadzira zvinodhaka kutungamira R&D, zvichiita kuti kubatanidza kwedu kuve kwakanyatso uye kushanda zvakanaka.
Isu takabatsira akati wandei epamusoro makambani emishonga emishonga, akadaiHansoh, Hengrui uye HEC Pharm.Pano ticharatidza chikamu chavo.
Customization Case One:
Cas Nha.: 110351-94-5
Customization Nyaya Yechipiri:
Cas Nha.: 144848-24-8
Customization Nyaya Yetatu:
Cas Nha.: 200636-54-0
1.Gadzirisa New Intermediates kana maAPI.Zvakangofanana nepamusoro pekugovanisa kesi, vatengi vane zvinodikanwa kune chaiwo maIntermediates kana APIs, uye havagone kuwana zvigadzirwa zvinodikanwa mumusika, saka isu tinogona kubatsira kuGadzirisa.
2.Process Optimization for Old Products.Chikwata chedu chichabatsira Kukwirisa nekuvandudza kugadzirwa kwakadai nzira yemaitiro yasakara, mutengo wekugadzira wakakwira, uye kushanda kwacho kwakadzikira.Tinogona kupa zvizere zvinyorwa zvekufambisa tekinoroji uye kuvandudzwa kwemaitiro, kubatsira mutengi kuti awedzere kugadzirwa.
Kubva pazvinangwa zvezvinodhaka kusvika kuINDs, JIN DUN Medical inokupa iweimwe-stop personalized R&D mhinduro.
JIN DUN Medical inoomerera pakugadzira timu ine zviroto, kugadzira zvigadzirwa zvine chiremera, zvine hungwaru, zvine hungwaru, uye kuenda zvese kunze kuti uve shamwari yakavimbika uye shamwari yevatengi!
