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3-(1-(Dimethylamino)ethyl]phenol

3-(1-(Dimethylamino)ethyl]phenol

Tsanangudzo Pfupi

CAS no:105601-04-5

Chemical properties: Rivastigmine tartrate Intermediates


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3- (1- (Dimethylamino) ethyl] phenol inoshandiswa sepakati peRivastigmine tartrate.
Rivastigmine tartrate is rivastigmine Alzheimer's disease drug, rivastigmine is physostigmine derivative by Novartis kekutanga yakabudirira kugadzira zita rekutengesa Exelon (exelon), mamorekuru ane ipapo carbamate chimiro, imhando yeamino acid yekusarudza cerebral cholinesterase inhibitor, inogona zvakare inhibitor. iyo acetylcholinesterase uye butyrylcholinesterase, cholinergic neurons nekunonoka kusunungurwa kweacetylcholine kuora uye simba rinokurudzira cholinergic nerve conduction, inogona kuvandudza kukanganisa kwehutano hwepfungwa kunopindirana necholinergic, nokudaro kuvandudza kushanda kwekuziva kwevarwere veAlzheimer's disease.Rivastigmine plasma protein binding haina simba, nyore nyore kuburikidza neropa-brain barriers, iyo ine hupamhi hwehuropi hwekusarudza.Haisi kungosarudza kuita pane inonyanya kukanganiswa cerebral cortex uye hippocampus, asi zvakare inodzivirira zvakanyanya subtype ye AChE muuropi, zvichikonzera kudzikiswa kwekuita kwe peripheral cholinergic side effects.Rivastigmine mu vivo hafu yehupenyu ipfupi uye yakareba nguva yekuita.Kusiyana netacrine, ichi chigadzirwa muhippocampus uye cortex yeG1 enzyme inhibitory effect yakasimba.Kliniki yekurapa nyoro kusvika pakati nepakati Alzheimer-type dementia, kana chirwere cheAlzheimer chinogona kufungirwa chirwere cheAlzheimer muchipatara.


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