4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl) -6-methoxy-2-methyl-5-pyrimidinamin;
Inoshanda nekukurudzira pakati presynaptic alpha 2- receptors.Iyo hypotensive effect yakafanana neye nifedipine, calcium antagonist, uye captopril, ACE inhibitor.Kune yakakosha hypertension.
Ichi chigadzirwa chinofanira kutora musimboti wemushonga wega wega.Kazhinji tanga kubva padanho rakaderera, kureva, 0.2mg, kamwe chete pazuva, inotorwa mangwanani.Kugadziriswa kwedosi kunofanirwa kuitwa pamavhiki matatu-nguva kusvika mhedzisiro inogutsa yawanikwa.Chiyero chinowanzoitwa 0.2mg kamwe, kaviri pazuva (mangwanani nemanheru).Chiyero chepamusoro panguva haifaniri kudarika 0.4mg, uye iyo yakawanda yezuva nezuva haifaniri kudarika 0.6mg.Kune varwere vane unyoro kana mwero renal insufficiency, iyo imwechete dose haifanire kudarika 0.2 mg kana zuva rega rega rega harifanire kudarika 0.4 mg.
Ichi chigadzirwa ndeye α2-receptor agonist, iyo imidazoline inorwisa hypertensive drug.Inoshandiswa kune yakadzikama uye yakaoma yekutanga uye yechipiri hypertension.
Nemhaka yokuti inodzivisa kuvharidzirwa uye kufamba kwegumbo remudumbu, inokodzerawo kune varwere vane hypertension vanotambura nechirwere cheronda.Iko kusanganiswa kwemushonga uyu uye diuretics kunogona kuvandudza zvakanyanya kushanda.Mushonga une simba wepakati weantihypertensive uye wechipiri-mutsara weantihypertensive mushonga.Inonyanya kupiwa munharaunda mune ophthalmology.Ichi chigadzirwa chine mhedzisiro yekudzikisa intraocular pressure, uye haikanganisi pupil uye ziso kugadzirisa mashandiro.Inogona kukanganisa tsinga dzeropa muziso, kuderedza kugadzirwa kweaqueous kuseka, uye kuwana mhedzisiro yekudzikisa intraocular pressure.Inotanga kuita maminetsi gumi nemashanu mushure mekunge ziso radonha uye inogona kuchengetedza mhedzisiro kwemaawa masere.
Standard:EP10
Assay content:97.5-102.0%
Kunze:Ichena kana kuti inenge iine hupfu
Package:1kg/bhegi kana sezvinodiwa nevatengi
JIN DUN Medical aneISO qualification uye inosangana neGMP yekugadzira zviyero, vakashandirwa mudzimba nevekunze nyanzvi dzekugadzira zvinodhaka vane ruzivo rwakapfuma kutungamira R&D yekambani.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Equipments
Yedu Lab ine midziyo yakasiyana-siyana yekuedza uye yekuedza, yakadai se: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Chikwata
Jindun Medical ine boka revashandi veR&D nyanzvi, uye inoshandisa nyanzvi zhinji dzemumba nedzekunze dzekugadzira zvinodhaka kutungamira R&D, zvichiita kuti kubatanidza kwedu kuve kwakanyatso uye kushanda zvakanaka.
Isu takabatsira akati wandei epamusoro makambani emishonga emishonga, akadaiHansoh, Hengrui uye HEC Pharm.Pano ticharatidza chikamu chavo.
Customization Case One:
Cas Nha.: 110351-94-5
Customization Nyaya Yechipiri:
Cas Nha.: 144848-24-8
Customization Nyaya Yetatu:
Cas Nha.: 200636-54-0
1.Gadzirisa New Intermediates kana maAPI.Zvakangofanana nepamusoro pekugovanisa kesi, vatengi vane zvinodikanwa kune chaiwo maIntermediates kana APIs, uye havagone kuwana zvigadzirwa zvinodikanwa mumusika, saka isu tinogona kubatsira kuGadzirisa.
2.Process Optimization for Old Products.Chikwata chedu chichabatsira Kukwirisa nekuvandudza kugadzirwa kwakadai nzira yemaitiro yasakara, mutengo wekugadzira wakakwira, uye kushanda kwacho kwakadzikira.Tinogona kupa zvizere zvinyorwa zvekufambisa tekinoroji uye kuvandudzwa kwemaitiro, kubatsira mutengi kuti awedzere kugadzirwa.
Kubva pazvinangwa zvezvinodhaka kusvika kuINDs, JIN DUN Medical inokupa iweimwe-stop personalized R&D mhinduro.
JIN DUN Medical inoomerera pakugadzira timu ine zviroto, kugadzira zvigadzirwa zvine chiremera, zvine hungwaru, zvine hungwaru, uye kuenda zvese kunze kuti uve shamwari yakavimbika uye shamwari yevatengi!
