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5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-imwe hydrochloride

5,6,7,7a-tetrahydrothieno(3,2-c)pyridine-2(4h)-imwe hydrochloride

Tsanangudzo Pfupi

CAS no:115473-15-9

Kemikari zvivakwa: Prasugrel Intermediates


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Uses

5,6,7,7a-tetrahydrothieno (3,2-c) pyridine-2 (4h) -one hydrochloride inoshandiswa sepakati pePrasugrel.

Prasugrel ndeye thiophenopyridine antiplatelet yakagadzirwa naEli Lilly uye daiichisankyo, muJapan anogadzira mishonga.I precursor drug.Inoumba molecule inoshanda mushure memetabolism kuburikidza ne cytochrome P450 muchiropa uye inosanganiswa neplatelet P2Y12 receptor kuti iite inoshanda kurwisa platelet aggregation.Zvidzidzo zvekiriniki zvakaratidza kuti 60 mg dose ine nani anticoagulant mhedzisiro pane 300 mg yakajairika dosi uye 600 mg yakawedzera dosi yeclopidogrel, iyo inogona kuderedza yakazara njodzi yekurwiswa kwemoyo, sitiroko uye kufa nekuda kwechirwere chemoyo ne20%, uye inokurumidza kuita. , yakanaka yekurapa maitiro, yakanaka kurwisa zvinodhaka uye bioavailability, uye yakaderera chepfu.


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