Guanosine

Guanosine inoshandiswa sepakati peValaciclovir.
Valacyclovir inonzi guanine analogue antiviral drug.Inoshandiswa mukurapa kwekiriniki yeherpes simplex uye herpes zoster utachiona muzvirwere zvepabonde.Ichi chigadzirwa ndicho chinotangira cheacyclovir.Inotorwa nekukurumidza mushure mekutonga kwemuromo uye nekukurumidza kushandurwa kuita acyclovir mumuviri.Iyo antiviral effect inoridzwa neacyclovir.Mushure mekunge acyclovir yapinda mumasero ane utachiona hweherpes, inokwikwidza ne deoxynucleoside yehutachiona thymidine deoxynucleoside kinase kana cell kinase, uye mushonga wacho uri phosphorylated mu activated acyclic guanosine triphosphate.Sechikamu chekudzokorora kwehutachiona, acyclovir inokwikwidza ne deoxyguanine triphosphate yevhairasi DNA polymerase, iyo inhibits virus DNA synthesis uye inoratidza antiviral maitiro.Iyo antiviral kuita kwechigadzirwa ichi mu vivo iri nani pane acyclovir, uye indekisi yekurapa yeherpes simplex virus type I uye Type II ndeye 42.91% uye 30.13% yakakwirira kupfuura acyclovir zvakateerana.Iyo zvakare ine yakanyanya kurapa mhedzisiro pavaricella zoster virus.