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Yakaderera MOQ Yekutengesa Kupisa!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

Yakaderera MOQ Yekutengesa Kupisa!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

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Kuve nhanho yekuzadzisa zviroto zvevashandi vedu!Kuvaka timu inofara, yakawedzera kubatana uye yakawedzera nyanzvi timu!Kuti tiwane mubairo wakawirirana wevatengi vedu, vatengesi, nzanga uye isu pachedu yeLow MOQ Yekutengesa Kupisa!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Isu takatendeseka uye takavhurika.Isu tinotarisa kumberi kwekumira uye nekumisikidza yakavimbika uye yenguva refu yakamira hukama hwerudo.
Kuve nhanho yekuzadzisa zviroto zvevashandi vedu!Kuvaka timu inofara, yakawedzera kubatana uye yakawedzera nyanzvi timu!Kuti tisvike kune mubairo wevatengi vedu, vatengesi, nzanga uye isu pacheduChina Pharmaceutical Intermediate uye 330942-05-7, "Unhu hwakanaka uye mutengo unonzwisisika" ndiyo mitemo yedu yebhizimisi.Kana iwe uchifarira mhinduro dzedu kana uine chero mibvunzo, yeuka kunzwa wakasununguka kutibata nesu.Tinovimba kumisa hukama hwekushandira pamwe newe munguva pfupi iri kutevera.

Fondaparinux Biological Activity

Rondedzera Fondaparinux sodium inonzi antithrombin-inotsamira chinhu Xa inhibitor.
RelatedCategories nzira yechiratidzo >> Metabolic enzymes/proteases >> Factor Xa Research nzvimbo >> Zvirwere zvemoyo
Target Factor Xa[1]
In vitrozvidzidzo Fondaparinux sodium ndiyo yekutanga anticoagulant itsva inonangana nechinhu Xa.Kune Fondaparinux, iyo IC50 kukosha (anti-Xa IU/ml) ye activated monocytes (ac-M) i 0.59±0.05, uye monocyte-inotorwa particles (MMP) i 0.17±0.03 [2].
In vivoresearch Fondaparinux sodium ine mutsara, dosi-inotsamira pharmacokinetic mbiri, iyo inopa mhinduro inofanotaurwa.Fondaparinux sodium ine 100% bioavailability, ine kukurumidza kutanga kwekuita, ine hafu yehupenyu hwemaawa gumi nemana kusvika ku16, uye inogona kuramba ichidzivisa thrombosis mukati maawa makumi maviri nemana.Mushonga haukanganisi nguva yeprothrombin kana kuti yakagadziriswa chikamu che thromboplastin nguva, uye haina kukanganisa kushanda kweplatelet kana kuunganidza [1].
References [1].Bauer KA.et al.Fondaparinux sodium: a selective inhibitor ye factor Xa.Am J Health Syst Pharm.2001 Nov 1;58 Suppl 2:S14-7.[2].Ben-Hadj-Khalifa S, nevamwe.Differential coagulation inhibitory effect ye fondaparinux, enoxaparin uye unfractionated heparin mumasero emhando ye thrombin generation.Ropa Coagul Fibrinolysis.2011 Jul;22(5):369-73.

Kemikari uye zvemuviri zvimiro zveFondaparinux

Molecular formula C31H53N3Na10O49S8
Molecular uremu 1738.16
PSA 900.82000

Fondaparinux rudzi rutsva rweantithrombotic drug yakabvumidzwa neFDA mushure meheparin uye yakaderera molecular weight heparin yekurapa nekudzivirira kwakasiyana arteriovenous thrombosis.

Zviratidzo: Fondaparinux inoshandiswa kune varwere vari kuvhiyiwa kukuru kwemapfupa emakumbo ezasi, zvakadai sekuputsika kwehudyu, kuvhiyiwa kukuru kwemabvi kana kuchinjwa kwehudyu, kudzivirira venous thromboembolism.Inoshandiswa pakurapa kwevarwere vane angina isina kugadzikana kana kuti isiri-ST-segment elevation myocardial infarction inopinda nokukurumidza (<120 maminitsi) invasive treatment (PCI) pasina chiratidzo.Inoshandiswa pakurapa varwere vane ST-segment elevation myocardial infarction vanoshandisa thrombolysis kana pakutanga vasingagamuchire mamwe maitiro ekurapazve.

1)Glaxo inoenderera mberi yekusimudzira musika ichaiisa munzvimbo yepakati pezvinodhaka munzira inotevera yekiriniki yeBazi rezvehutano, shanduko yemitengo yeNational Development and Reform Commission, uye inishuwarenzi yekurapa yeBazi rePeople's Inishuwarenzi.

A、Chigadzirwa hachisati chapinda muinishuwarenzi yenyika.Muna 2010, gadziriso yeinishuwarenzi yekurapa ichangopinda muinishuwarenzi yemunharaunda yematunhu gumi nematanhatu.Kutengesa kuri padanho rekutanga uye zvishoma nezvishoma kutsiva yakaderera-molecular-uremu heparin musika;mapurovhinzi einishuwarenzi yezvokurapa: Shaanxi, Shanxi, Inner Mongolia, Liaoning, Tibet, Yunnan, Guangdong , Guangxi, Hainan, Jiangsu, Gansu, Fujian, Jiangxi, Henan, Hubei, Beijing.

B, Zvinoratidza zvichiri kuwedzera.GSK parizvino ine 3 zviratidzo mukiriniki.Semuenzaniso, zviratidzo zve stents zvinotenderwa chete.Mamwe maheparin haawaniki.Kushandiswa kwekiriniki kwema stents kunowedzera ne30% gore negore.Nekubvumirwa kwezviratidzo zvitsva, kutengesa kuchawedzera.Mune dzidziso, zvirwere zvese zvinorapwa neheparin akatevedzana zvigadzirwa zvinogona kurapwa nechigadzirwa ichi.

C、Mutengo wakanakira, mutengo wakaderera wechigadzirwa ichi mumusika weUS madhora zana nemakumi matatu nemaviri emadhora, muChina i168 yuan, mutengo wepamba hauzodonha.Kana iwe uchiita kunze kwenyika, musika wepasi rose une nzvimbo yakafara;

2) Chikumbaridzo chehunyanzvi chakakwira, iyo mbishi inogadzirwa mumatanho makumi manomwe neshanu, uye patent yapera kwemakore mashanu (chinyorwa muna 2014).Izvo hazvina kubvumidzwa nevamwe vanogadzira.Iyo synthesis yakaoma zvakanyanya.Hazvizoitwe mukati memakore asingasviki gumi.Kutenderera kwakareba, kwakaoma, uye kuisa mari.high.Kune vashoma vakwikwidzi vemumba, uye vakwikwidzi vekunze vane mitengo yakakwira yezvigadzirwa.Chinangwa chedu ndechekuramba tichidzikisira mutengo wemidziyo uye kutsiva Glaxo mukugadzirwa kwezvinhu.
Hengrui Pharmaceuticals Fondaparinux yakabvumidzwa seyekutanga kutevedzera muChina 2018.
Guangdong Runxing Biotechnology Co., Ltd. ine gore negore kuburitsa kwe210 kg ye fondaparinux sodium yepamusoro yepakati N3, iyo ichaiswa muna 2018.

Fondaparinux yakatanga kugadzirwa neMYLAN IRELAND.Parizvino, Hengrui Pharmaceuticals, Borui Pharmaceuticals, Haisco.

Kuve nhanho yekuzadzisa zviroto zvevashandi vedu!Kuvaka timu inofara, yakawedzera kubatana uye yakawedzera nyanzvi timu!Kuti tiwane mubairo wakawirirana wevatengi vedu, vatengesi, nzanga uye isu pachedu yeLow MOQ Yekutengesa Kupisa!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7, Isu takatendeseka uye takavhurika.Isu tinotarisa kumberi kwekumira uye nekumisikidza yakavimbika uye yenguva refu yakamira hukama hwerudo.
Yakaderera MOQ yeChina Pharmaceutical Intermediate uye 330942-05-7, "Unhu hwakanaka uye mutengo unonzwisisika" ndiyo mitemo yedu yebhizimisi.Kana iwe uchifarira mhinduro dzedu kana uine chero mibvunzo, yeuka kunzwa wakasununguka kutibata nesu.Tinovimba kumisa hukama hwekushandira pamwe newe munguva pfupi iri kutevera.


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