Vhiki rino, bepanhau repamusoro rezvidzidzo Nature rakaburitsa bepa rekutsvagisa pamhepo nechikwata chaProfessor Feng Liang kuStanford University, richiburitsa chimiro uye mashandiro eropa-brain barrier lipid transport protein MFSD2A.Kuwanikwa uku kunobatsira kugadzira mishonga yekudzora kupinza kweropa-brain barriers.
MFSD2A inotakura phospholipid iyo inokonzera kutora docosahexaenoic acid muuropi mumasero endothelial anoumba ropa-brain barriers.Docosahexaenoic acid inozivikanwa zviri nani seDHA, iyo yakakosha mukusimudzira nekuita kwehuropi.Kuchinja kunobata basa reMFSD2A kunogona kukonzera dambudziko rekukura rinonzi microcephaly syndrome.
Iyo lipid yekufambisa kugona kweMFSD2A inoreva zvakare kuti puroteni iyi yakanyatso hukama nekuvimbika kweropa-brain barriers.Zvidzidzo zvakapfuura zvakaona kuti kana basa rayo raderedzwa, iyo yeropa-brain barriers inodonha.Naizvozvo, MFSD2A inoonekwa senge inovimbisa yekudzora chinja pazvinenge zvakakodzera kuyambuka ropa-brain barriers kuendesa mishonga yekurapa muuropi.
Muchidzidzo ichi, timu yaProfessor Feng Liang yakashandisa tekinoroji ye-cryo-electron microscopy kuwana iyo yakakwirira-resolution chimiro chegonzo MFSD2A, ichiburitsa yakasarudzika nzvimbo yekunze uye substrate inosunga mhango.
Kubatanidza ongororo yekushanda uye mashefu ekufananidza, vaongorori vakaratidzawo nzvimbo dzakachengetwa dzesodium inosunga muchimiro cheMFSD2A, ichiburitsa nzira dzekupinda lipid, uye zvichibatsira kunzwisisa kuti nei chaiyo MFSD2A shanduko ichikonzera microcephaly syndrome.
Nguva yekutumira: Sep-01-2021