PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 ine Mutengo Wakanakisisa

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PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 ine Mutengo Wakanakisisa

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Isu tinopawo chigadzirwa kana sevhisi kutsvaga uye makambani ekubatanidza ndege.Tine yedu yekugadzira unit uye hofisi yekutsvaga.Tinogona kukupa nyore nyore dzinenge mhando dzese dzekutengesa dzakafanana nemhando yechigadzirwa yedu yePriceList yeHigh Quality Antiviral Entecavir Powder CAS 142217-69-4 neMutengo Wakanyanya, Isu tiri kuramba tichiedza kuwedzera kambani yedu uye nekupa izvo zvemhando yepamusoro zvigadzirwa. ine hutsinye hwemitengo.Chero kubvunza kana kutaura kunoyemurwa zvakanyanya.Rangarira kutibata wakasununguka.
Isu tinopawo chigadzirwa kana sevhisi kutsvaga uye makambani ekubatanidza ndege.Tine yedu yekugadzira unit uye hofisi yekutsvaga.Isu tinokwanisa kukupa zviri nyore kune dzinenge mhando dzese dzekutengesa dzakafanana nemhando yezvigadzirwa zveduChina Entecavir uye 142217-69-4, Tinogamuchira noushamwari vatengi vekumba nevemhiri kwemakungwa kuti vashanyire kambani yedu uye tive nehurukuro yebhizinesi.Kambani yedu inogara ichisimbirira pamusimboti we "mhando yakanaka, mutengo unonzwisisika, yekutanga-kirasi sevhisi".Isu takagadzirira kuvaka kushandira pamwe kwenguva refu, hushamwari uye kunobatsira pamwe newe.

Entecavir (SQ 34676;BMS 200475) inosarudza uye inoshanda HBV Inhibitor.MuHepG2 maseru EC50 kukosha ndeye 3.75 nM.Mishonga yemazuva ano inorwisa hepatitis B uye anti-AIDS yekutanga.

Entecavir mhedzisiro

Ichi chigadzirwa chinonzi guanine nucleoside analog, ine inhibitory effect pahutachiona hwehepatitis B (HBV) polymerase.Inogona kuva phosphorylated kuita triphosphate inoshanda, uye hafu yehupenyu hwe triphosphate muchitokisi maawa gumi nemashanu.Nokukwikwidzana neHBV polymerase's natural substrate deoxyguanosine triphosphate, entecavir triphosphate inogona kudzivisa mabasa ose matatu ehutachiona hwepolymerase (reverse transcriptase): (1) HBV polymerase initiation;(2) pregenomic mRNA Kuumbwa kweiyo yakaipa strand ye reverse transcription;(3) Kuumbwa kwetambo yakanaka yeHBV DNA.Iyo inhibitory constant (Ki) ye entecavir triphosphate paHBV DNA polymerase ndeye 0.0012μM.Entecavir triphosphate ine simba inhibitory effect pane cell α, β, δ DNA polymerase uye mitochondrial γ DNA polymerase, ine Ki kukosha kwe18 kusvika ku160 μM.

Rondedzera	Entecavir (SQ 34676;BMS 200475) inosarudza uye inoshanda HBV Inhibitor.MuHepG2 maseru EC50 kukosha ndeye 3.75 nM.
Relatedmapoka	nzira yechiratidzo >> Anti-infective >> HBV Research nzvimbo >> Infect
Target	EC50: 3.75 nM (anti-HBV, HepG2 sero)[2]
In vitrozvidzidzo	Iyo EC50 yeBMS-200475 kusvika kuHBV ndeye 3.75 nM.Inosanganiswa muHBV protein primers, uye ipapo danho rekutanga reverse transcriptase rinodzivirirwa.Iyo antiviral chiitiko cheBMS-200475 yakaderera zvakanyanya kupfuura mamwe maRNA neDNA mavhairasi [1].Kuenzaniswa nedzimwe deoxyguanosine analogs (penciclovir, ganciclovir, lobucavir uye acyclovir) kana lamivudine, entecavir inowanzoita phosphorylated kune metabolite yayo inoshanda.Iyo intracellular hafu yeupenyu yeEntecavir ndeye 15 maawa [2].
In vivoresearch	BMS-200475 inobatwa nemuromo zuva rega rega nedoro kubva ku0.02 kusvika ku0.5 mg / kg uremu hwemuviri kwemwedzi 1 kusvika ku3, iyo inogona kunyatsodzikisa huwandu hwehunichuck hepatitis virus (WHV) viremia muhuni husina hutachiwana husingagumi [3].
Seroexperiment	BMS 200475 inogadzirwa muphosphate buffered saline (PBS) uye yakanyungudutswa nepakati yakakodzera ine 2% fetal bovine serum.HepG2 2.2.15 masero akadyarwa pa 12-tsime Biocoat collagen-coated plate pa density ye 5 × 10 5 masero 5 patsime, uye akachengetwa munzvimbo yakasangana kwemazuva 2 kusvika 3, uyezve yakavharwa ne1 mL yeBMS 200475. pakati .HBV quantification yakaitwa pazuva regumi [1].
References	[1].Innaimo SF, nevamwe.Kuzivikanwa kweBMS-200475 seine simba uye inosarudza inhibitor yehutachiona hweH hepatitis B.Antimicrob Agents Chemother.1997 Jul;41(7):1444-9[2].Rivkin A, nevamwe.Kuongororwa kwe entecavir mukurapa kwechirwere chisingaperi chehepatitis B.Curr Med Res Opin.2005 Nov;21(11):1845-57.[3].Genovesi EV, et al.Kubudirira kweiyo carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 muwoodchuck modhi yehutachiona hwehepatitis B.Antimicrob Agents Chemother.1998 Dec;42(12):3209-18.

Zvenyama uye zvemakemikari zvimiro zveEntecavir

Density	1.8±0.1 g/cm³
Boiling point	734.2ºC pa760 mmHg
Melting point	249-252ºC
Molecular formula	C12H15N5O3
Molecular uremu	277.279
Flash point	397.9ºC
Hunhu chaihwo	277.117493
PSA	130.05000
LogP	-0.96
Chitarisiko hunhu	Ichena kusvika kune-chena / yero crystalline poda
Refractive index	1.837
Kuchengetedza mamiriro	-20°C Mufiriza

Entecavir Customs

Customs code	2933990099
Chinese Overview	2933990099. Mimwe mishonga yeheterocyclic ine chete nitrogen heteroatoms.Kukosha-yakawedzerwa mutero wemutero: 17.0%.Mutero wekudzoserwa kwemutero: 13.0%.Regulatory mamiriro: Hapana.Inonyanya kufarirwa nyika mutero: 6.5%.General tariff: 20.0%
Declaration elements	Zita rechigadzirwa, ingredient yemukati, shandisa, hexamethylene chloride, ndapota ratidza chitarisiko, 6-caprolactam, ndapota ratidza chitarisiko, kusaina zuva.
Summary	2933990090. heterocyclic compounds nenitrogen hetero-atomu(s) chete.VAT:17.0%.Mutero wekudzoserwa kwemutero: 13.0%..MFN mutero: 6.5%.General tariff:20.0%

Rumwe ruzivo:

Qu Qiang (PhD muchipatara pharmacology, Dhipatimendi rePharmacy, Xiangya Hospital, Central South University) uye Wang Ruoguang (Chiremba weMishonga, postdoctoral in biology, Changsha Ruoguang Medical Research Center) akanyorawo kuti: muchirongwa che entecavir, entecavir inogona kutorwa. kwemakore akati wandei kana kunyange gumi.Kupfuura makore.Uye inogona kushandiswa nevakadzi vane pamuviri, vachiratidza kuchengeteka kwakanaka.

Tichitarisa kubva kune aya anozivikanwa ma molecular pharmacological mechanisms, Entecavir inogona kuva ne-broad-spectrum antiviral effect, kwete chete inoshanda kurwisana neHBV.

Isu tinowanzo shandisa Entecavir kurapa hutachiona hwehutachiona hwehutachiona mukiriniki, uye mhedzisiro yacho inoshamisa.

Parizvino, mukutarisisa kwevanopfuura mazana mashanu evarwere veCOVID19 muHubei (nzvimbo), munhu mumwe chete akatora entecavir.Nguva yekunyora yaiva kutanga kwaJanuary, uye ipapo mushonga wacho wakamiswa.

Ndichiri kutsigira vashandi vekurapa muHubei, vamwe vanachiremba vepasi, kana mapoka ane njodzi, parizvino ari kushandisa Entecavir kudzivirira COVID19, hapana nyaya yehutachiona.Vanhu vanofungidzirwa kuti vanotora entecavir, hapana akafambira mberi kuti aonekwe aine COVID19.

Patent nyaya:

Iko kune kunyanya maviri maitiro, 06 maitiro uye 89 maitiro.Kupera kwepatent ye06 process kwave kumberi (inopera muna 2023)!Kunyange zvazvo mutengo wekugadzirisa wakaderera, hutano huri hwakanaka, uye vashandi vanogona kuva vakasimba, mazano ega: Pamiti yemakemikari, shandisa nzira ye06 kuti usanyanya kuzvikudza;kumakambani emishonga, usatore fluke uye usanyanya kuve nengozi.

Muna 2014, Chia Tai Tianqing akawana kutengesa kwegore negore kwe 10 bhiriyoni yuan kuburikidza nekuvimba nemishonga yemagetsi yakadai se entecavir, iyo entecavir yakaverengera 20%.

Sezvo entecavir yakabvumirwa kutengeswa muna 2005, kupfuura 100 makambani emishonga epamba akanyorera kunyoreswa kwechigadzirwa;pakati pavo, makambani ekugadzira akatenderwa anosanganisira Jiangsu Zhengda Tianqing Pharmaceutical (yekutanga kutevedzera), Hainan Zhonghe Pharmaceutical, uye Fujian Guangxi Pharmaceutical Co., Ltd. Shengtang Pharmaceutical, Jiangxi Qingfeng Pharmaceutical, Suzhou Dawnrays Pharmaceutical, Shanghai Pharmaceutical Pharmaceutical, Singchungdong Haing Lukang, Zhejiang Huasheng Biopharmaceutical, Changzhi Sanbao Biochemical.

Pharmaceutical, Anhui Baker Biopharmaceutical, Hunan Concord Pharmaceutical Industry, Beijing Xiehe Pharmaceutical Factory, Beijing Baiao Pharmaceutical, Xinlitai Pharmaceutical, Dongyangguang, nezvimwewo;kubva pazuva rechibvumirano, chigadzirwa ichi chakapinda mumhando yemhando dzakakurumbira dzakaziviswa kubvira 2007.

Isu tinopawo chigadzirwa kana sevhisi kutsvaga uye makambani ekubatanidza ndege.Tine yedu yekugadzira unit uye hofisi yekutsvaga.Tinogona kukupa nyore nyore dzinenge mhando dzese dzekutengesa dzakafanana nemhando yechigadzirwa yedu yePriceList yeHigh Quality Antiviral Entecavir Powder CAS 142217-69-4 neMutengo Wakanyanya, Isu tiri kuramba tichiedza kuwedzera kambani yedu uye nekupa izvo zvemhando yepamusoro zvigadzirwa. ine hutsinye hwemitengo.Chero kubvunza kana kutaura kunoyemurwa zvakanyanya.Rangarira kutibata wakasununguka.
PriceList yeChina Entecavir uye 142217-69-4, Tinogamuchira noushamwari vatengi vekumba nevemhiri kwemakungwa kuti vashanyire kambani yedu uye tive nehurukuro yebhizinesi.Kambani yedu inogara ichisimbirira pamusimboti we "mhando yakanaka, mutengo unonzwisisika, yekutanga-kirasi sevhisi".Isu takagadzirira kuvaka kushandira pamwe kwenguva refu, hushamwari uye kunobatsira pamwe newe.

Zvakapfuura: PriceList for High Quality Antiviral Entecavir Powder CAS 142217-69-4 ine Mutengo Wakanakisisa

Zvinotevera: Yakaderera MOQ Yekutengesa Kupisa!Factory Supply High Quality Betrixaban Raw Materials CAS 330942-05-7

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