(R)-8-(3-Amino-piperidin-1-yl)-7-asi-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
(R)-8-(3-Amino-piperidin-1-yl)-7-asi-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3
Linagliptin Linagliptin, yakagadzirwa naBoehringer Ingelheim, yakagamuchirwa neFDA musi waMay 2, 2011. Inoshandiswa kubatanidza kudya uye kurovedza muviri kuvandudza kutonga kwemazinga eglucose muropa muvanhu vane chirwere cheshuga chechipiri.Linagliptin inovandudza kudzora shuga yeropa muvarwere nekudzivisa dipeptidyl peptidase-4 (DPP-4).
Incretin (Incretin) ine mhedzisiro yekusimudzira secretion ye insulin nepancreatic islet B masero, kunyanya kusanganisira glucose-inotsamira insulinotropic polypeptide (GIP) uye glucagon-like polypeptide-1 (GLP-1).DDP-4 is serine protease iri pamusoro pemasero.Inosunga mapuroteni uye inowanikwa zvakanyanya mu plasma uye zvakasiyana-siyana zvinyama mumuviri (zvakadai seitsvo, chiropa, duku intestinal villi, endothelial cells, nezvimwewo).Linagliptin inosarudzika DPP-4 inhibitor iyo inhibitor inhibitor iyo inhibitor iyo inhibitor inomisa basa re enzyme nekudzokera kumashure kusungirira kuDPP-4, inonoke kushatisa kweGLP-1, inosimudzira basa reGLP-1, uye inomutsa nenzira inotsamira glucose-inoenderana neInsulin. inoderedza mwero weglucagon mukutenderera, nekudaro ichigadzirisa chiyero cheglucose yeropa yevarwere vane Type 2 chirwere cheshuga.
Kuenzaniswa nemamwe DPP-4 inhibitors, izvo zvakakosha zveLinagliptin ndezvekuti: ine yakanakisa kuchengetedza renal uye inogona kunyatso kudzikisa glycosylated hemoglobin.Linagliptin inonyanya kubudiswa mutsvina mune prototype fomu.Mushure mekutonga nemuromo, iyo renal excretion inongova 5% yehuwandu hunopihwa.Kunyange kana ikaitwa intravenously, 30.8% chete inobudiswa kuburikidza neitsvo.Naizvozvo, hapana chikonzero chevarwere vari kurapwa.Nguva dzose tarisa chiropa uye itsvo kushanda uye kugadzirisa dose.Vese varwere vanogona kugadzirisa zvakafanana dosi kuti vanyorerwe nyore.
Zvakajairwa zvakaipa zvinokonzeresa zveLinagliptin kutapukira kwekufema, kusangana kwemhino, kurwadziwa kwemhasuru, musoro uye kurwadziwa nehuro.
Executive standard:bhizinesi standard
Assay:98-102%
Kunze:Hupfu hwakachena kusvika kuyero
Package:25kg / chigubhu
JIN DUN Medical aneISO qualification uye inosangana neGMP yekugadzira zviyero, vakashandirwa mudzimba nevekunze nyanzvi dzekugadzira zvinodhaka vane ruzivo rwakapfuma kutungamira R&D yekambani.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Equipments
Yedu Lab ine midziyo yakasiyana-siyana yekuedza uye yekuedza, yakadai se: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Chikwata
Jindun Medical ine boka revashandi veR&D nyanzvi, uye inoshandisa nyanzvi zhinji dzemumba nedzekunze dzekugadzira zvinodhaka kutungamira R&D, zvichiita kuti kubatanidza kwedu kuve kwakanyatso uye kushanda zvakanaka.
Isu takabatsira akati wandei epamusoro makambani emishonga emishonga, akadaiHansoh, Hengrui uye HEC Pharm.Pano ticharatidza chikamu chavo.
Customization Case One:
Cas Nha.: 110351-94-5
Customization Nyaya Yechipiri:
Cas Nha.: 144848-24-8
Customization Nyaya Yetatu:
Cas Nha.: 200636-54-0
1.Gadzirisa New Intermediates kana maAPI.Zvakangofanana nepamusoro pekugovanisa kesi, vatengi vane zvinodikanwa kune chaiwo maIntermediates kana APIs, uye havagone kuwana zvigadzirwa zvinodikanwa mumusika, saka isu tinogona kubatsira kuGadzirisa.
2.Process Optimization for Old Products.Chikwata chedu chichabatsira Kukwirisa nekuvandudza kugadzirwa kwakadai nzira yemaitiro yasakara, mutengo wekugadzira wakakwira, uye kushanda kwacho kwakadzikira.Tinogona kupa zvizere zvinyorwa zvekufambisa tekinoroji uye kuvandudzwa kwemaitiro, kubatsira mutengi kuti awedzere kugadzirwa.
Kubva pazvinangwa zvezvinodhaka kusvika kuINDs, JIN DUN Medical inokupa iweimwe-stop personalized R&D mhinduro.
JIN DUN Medical inoomerera pakugadzira timu ine zviroto, kugadzira zvigadzirwa zvine chiremera, zvine hungwaru, zvine hungwaru, uye kuenda zvese kunze kuti uve shamwari yakavimbika uye shamwari yevatengi!
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