3-(1-(Dimethylamino)ethyl]phenol
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3-(1-(Dimethylamino)ethyl]phenol
3- (1- (Dimethylamino) ethyl] phenol inoshandiswa sepakati peRivastigmine tartrate.
Rivastigmine tartrate is rivastigmine Alzheimer's disease drug, rivastigmine is physostigmine derivative by Novartis kekutanga yakabudirira kugadzira zita rekutengesa Exelon (exelon), mamorekuru ane ipapo carbamate chimiro, imhando yeamino acid yekusarudza cerebral cholinesterase inhibitor, inogona zvakare inhibitor. iyo acetylcholinesterase uye butyrylcholinesterase, cholinergic neurons nekunonoka kusunungurwa kweacetylcholine kuora uye simba rinokurudzira cholinergic nerve conduction, inogona kuvandudza kukanganisa kwehutano hwepfungwa kunopindirana necholinergic, nokudaro kuvandudza kushanda kwekuziva kwevarwere veAlzheimer's disease.Rivastigmine plasma protein binding haina simba, nyore nyore kuburikidza neropa-brain barriers, iyo ine hupamhi hwehuropi hwekusarudza.Haisi kungosarudza kuita pane inonyanya kukanganiswa cerebral cortex uye hippocampus, asi zvakare inodzivirira zvakanyanya subtype ye AChE muuropi, zvichikonzera kudzikiswa kwekuita kwe peripheral cholinergic side effects.Rivastigmine mu vivo hafu yehupenyu ipfupi uye yakareba nguva yekuita.Kusiyana netacrine, ichi chigadzirwa muhippocampus uye cortex yeG1 enzyme inhibitory effect yakasimba.Kliniki yekurapa nyoro kusvika pakati nepakati Alzheimer-type dementia, kana chirwere cheAlzheimer chinogona kufungirwa chirwere cheAlzheimer muchipatara.
JIN DUN Medical aneISO qualification uye inosangana neGMP yekugadzira zviyero, vakashandirwa mudzimba nevekunze nyanzvi dzekugadzira zvinodhaka vane ruzivo rwakapfuma kutungamira R&D yekambani.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Equipments
Yedu Lab ine midziyo yakasiyana-siyana yekuedza uye yekuedza, yakadai se: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Chikwata
Jindun Medical ine boka revashandi veR&D nyanzvi, uye inoshandisa nyanzvi zhinji dzemumba nedzekunze dzekugadzira zvinodhaka kutungamira R&D, zvichiita kuti kubatanidza kwedu kuve kwakanyatso uye kushanda zvakanaka.
Isu takabatsira akati wandei epamusoro makambani emishonga emishonga, akadaiHansoh, Hengrui uye HEC Pharm.Pano ticharatidza chikamu chavo.
Customization Case One:
Cas Nha.: 110351-94-5
Customization Nyaya Yechipiri:
Cas Nha.: 144848-24-8
Customization Nyaya Yetatu:
Cas Nha.: 200636-54-0
1.Gadzirisa New Intermediates kana maAPI.Zvakangofanana nepamusoro pekugovanisa kesi, vatengi vane zvinodikanwa kune chaiwo maIntermediates kana APIs, uye havagone kuwana zvigadzirwa zvinodikanwa mumusika, saka isu tinogona kubatsira kuGadzirisa.
2.Process Optimization for Old Products.Chikwata chedu chichabatsira Kukwirisa nekuvandudza kugadzirwa kwakadai nzira yemaitiro yasakara, mutengo wekugadzira wakakwira, uye kushanda kwacho kwakadzikira.Tinogona kupa zvizere zvinyorwa zvekufambisa tekinoroji uye kuvandudzwa kwemaitiro, kubatsira mutengi kuti awedzere kugadzirwa.
Kubva pazvinangwa zvezvinodhaka kusvika kuINDs, JIN DUN Medical inokupa iweimwe-stop personalized R&D mhinduro.
JIN DUN Medical inoomerera pakugadzira timu ine zviroto, kugadzira zvigadzirwa zvine chiremera, zvine hungwaru, zvine hungwaru, uye kuenda zvese kunze kuti uve shamwari yakavimbika uye shamwari yevatengi!
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