Guanosine
Guanosine
Guanosine inoshandiswa sepakati peValaciclovir.
Valacyclovir inonzi guanine analogue antiviral drug.Inoshandiswa mukurapa kwekiriniki yeherpes simplex uye herpes zoster utachiona muzvirwere zvepabonde.Ichi chigadzirwa ndicho chinotangira cheacyclovir.Inotorwa nekukurumidza mushure mekutonga kwemuromo uye nekukurumidza kushandurwa kuita acyclovir mumuviri.Iyo antiviral effect inoridzwa neacyclovir.Mushure mekunge acyclovir yapinda mumasero ane utachiona hweherpes, inokwikwidza ne deoxynucleoside yehutachiona thymidine deoxynucleoside kinase kana cell kinase, uye mushonga wacho uri phosphorylated mu activated acyclic guanosine triphosphate.Sechikamu chekudzokorora kwehutachiona, acyclovir inokwikwidza ne deoxyguanine triphosphate yevhairasi DNA polymerase, iyo inhibits virus DNA synthesis uye inoratidza antiviral maitiro.Iyo antiviral kuita kwechigadzirwa ichi mu vivo iri nani pane acyclovir, uye indekisi yekurapa yeherpes simplex virus type I uye Type II ndeye 42.91% uye 30.13% yakakwirira kupfuura acyclovir zvakateerana.Iyo zvakare ine yakanyanya kurapa mhedzisiro pavaricella zoster virus.
JIN DUN Medical aneISO qualification uye inosangana neGMP yekugadzira zviyero, vakashandirwa mudzimba nevekunze nyanzvi dzekugadzira zvinodhaka vane ruzivo rwakapfuma kutungamira R&D yekambani.
TECHNOL OGY ADVANTAGES
●High Pressure Catalytic Hydrogenation .High Pressure Hydrogenolysis Reaction .Cryogenic Reaction (<-78%C)
●Aromatic Heterocyclic Synthesis
● Rearrangement Reaction
●Chiral Resolution
●Heck, Suzuki,Negishi,Sonogashira .Gignard Reaction
Equipments
Yedu Lab ine midziyo yakasiyana-siyana yekuedza uye yekuedza, yakadai se: NMR (Bruker 400M), HPLC, chiral-HPLC, LC-MS, LC-MS/MS (API 4000), IR, UV, GC, GC-MS, Chromatography, Microwave Synthesizer, Parallel Synthesizer, Differential Scanning Calorimeter (DSC), Electron Microscope...
R&D Chikwata
Jindun Medical ine boka revashandi veR&D nyanzvi, uye inoshandisa nyanzvi zhinji dzemumba nedzekunze dzekugadzira zvinodhaka kutungamira R&D, zvichiita kuti kubatanidza kwedu kuve kwakanyatso uye kushanda zvakanaka.
Isu takabatsira akati wandei epamusoro makambani emishonga emishonga, akadaiHansoh, Hengrui uye HEC Pharm.Pano ticharatidza chikamu chavo.
Customization Case One:
Cas Nha.: 110351-94-5
Customization Nyaya Yechipiri:
Cas Nha.: 144848-24-8
Customization Nyaya Yetatu:
Cas Nha.: 200636-54-0
1.Gadzirisa New Intermediates kana maAPI.Zvakangofanana nepamusoro pekugovanisa kesi, vatengi vane zvinodikanwa kune chaiwo maIntermediates kana APIs, uye havagone kuwana zvigadzirwa zvinodikanwa mumusika, saka isu tinogona kubatsira kuGadzirisa.
2.Process Optimization for Old Products.Chikwata chedu chichabatsira Kukwirisa nekuvandudza kugadzirwa kwakadai nzira yemaitiro yasakara, mutengo wekugadzira wakakwira, uye kushanda kwacho kwakadzikira.Tinogona kupa zvizere zvinyorwa zvekufambisa tekinoroji uye kuvandudzwa kwemaitiro, kubatsira mutengi kuti awedzere kugadzirwa.
Kubva pazvinangwa zvezvinodhaka kusvika kuINDs, JIN DUN Medical inokupa iweimwe-stop personalized R&D mhinduro.
JIN DUN Medical inoomerera pakugadzira timu ine zviroto, kugadzira zvigadzirwa zvine chiremera, zvine hungwaru, zvine hungwaru, uye kuenda zvese kunze kuti uve shamwari yakavimbika uye shamwari yevatengi!
