2-butyl-5-nitro-3-benzofuranyl) [4--[3-(dibutylaMino) propoxy]phenyl]

Inoshandiswa muchipatara mukutanga uye yechipiri Hyperuricemia, kunyanya kune varwere vane hyperuricemia, pamwe chete nevarwere vane renal insufficiency, uye kune varwere vane gout inowanzoitika kana isingagumi, pamwe chete nevarwere vane hyperuricemia.Inoshandiswa kune varwere vane Gouty nephropathy kuderedza zviratidzo uye kuderedza kuumbwa kwerenal uric acid matombo;gout stones;inoshandiswa muuric acid itsvo matombo uye uric acid chirwere chetsvo.

Mushonga mutsva unorwisa arrhythmic Atrial fibrillation (AF) chirwere chinogona kuuraya hupenyu.Nekuda kwekuchembera kwevanhu, chiitiko chepasi rose uye kufa kweatrial fibrillation kuri kuwedzera, uye yave dambudziko idzva rehutano hweveruzhinji.Kune varwere vane 2.5 miriyoni vane atrial fibrillation muUnited States uye 4.5 miriyoni muEuropean Union.Maererano nehuwandu, kuwanda kweatrial fibrillation pakati pevanhu vanopfuura makore makumi matatu munyika yangu ndeye 0.77%, iyo inowedzera nezera, uye varume vakakwirira kudarika vakadzi (0.9%: 0.7%).Zvirwere zvinokonzeresa fibrillation yeatrial kunyanya zvinosanganisira hypertension, chirwere chemwoyo, chirwere chemoyo chevalvular, spontaneous dilated cardiomyopathy, uye kusagadzikana kwemoyo.Chiratidzo chikuru chevarwere vane atrial fibrillation isingaenzaniswi ventricular rate, uye kutonga kwemwoyo kunotora imwe nzvimbo mukurapa kwakanyanya uye kuchengetedza zviratidzo.Amiodarone inobata basa rakanaka mukudzora kurova kwemoyo uye kudzorera sinus rhythm, asi migumisiro yakaipa yenhengo dzakanangwa dzine chokuita nechikamu cheiodine muhutano hwayo inoderedza kushandiswa kwayo kwekliniki, zvakadai sekukuvadza kumapapu, thyroid, uye chiropa.Izvo zvataurwa pamusoro apa zvakashata uye maitiro ayo Iyo iodine mukati inofambidzana zvakanyanya.Iyo itsva antiarrhythmic drug Dronedarone (Dronedarone) yakawanikwa nekugadzirisa maitiro eamiodarone.Dronedarone ine electrophysiological properties yakafanana neamiodarone, asi haina iodine muhutano hwayo, saka inogona kudzivisa zvakakomba zvekuwedzera kwemwoyo zvinokonzerwa neodine Chemicalbook.Dronedarone yakabvumirwa kutengeswa neU.S. Food and Drug Administration (FDA) muna July 2009, uye yakabvumirwa kutengeswa muEuropean Union mu 2009. Ndiyowo yekutanga itsva antiarrhythmic drug yakagamuchirwa muEuropean Union mumakore gumi.Dronedarone inonzi N- [2-butyl-3-[4- [3- (dibutylamino)) propoxy] phenyl] -5-benzofuranyl]-methanesulfonamide, iyo inoderedza A benzofuran derivative inowanikwa nekugadziriswa kwemaitiro eamiodarone, iyo isiri cardiac adverse reaction.Inobvisa atomu yeiodine muamiodarone kuderedza huturu hwetroroid nedzimwe nhengo;inowedzera boka remethylsulfonyl padivi rebenzofuran kuderedza lipophilicity, nokudaro kupfupisa hafu yeupenyu hwemushonga uye kuderedza kuunganidzwa kwematishu uye mukana wemushonga We neurotoxicity.Zvose 2011 US version uye 2010 European version yeAtrial Fibrillation Guidelines inokurudzira dronedarone yekurapa kweatrial fibrillation.Dronedarone yakachengeteka uye inoshanda mukurapa ventricular rate uye kuchengetedza sinus rate muvarwere vakasiyana-siyana vasina AF yakaoma.Inogona kuva mushonga unoshanda kutsiva amiodarone.Dronedarone inogonawo kuderedza kufa kwevarwere veAF uye kunyange vanoramba vari varwere veAF.Naizvozvo, zvinotarisirwa kuve mushonga wekutanga wevarwere veAF vasina kutadza kwakanyanya kwemoyo.Uyezve, kushandiswa kwemaanticoagulants muvarwere vepakati-panjodzi yeAF kunobatsira kushandiswa kwedronedarone.